It depends on whether your host has integrated graphics or a second GPU for the hypervisor. If the host can keep its own display adapter, other VMs like Home Assistant on Proxmox run independently and aren’t affected by the GPU being passed through to a different VM. Security note: IOMMU configuration and kernel parameters affect system-level isolation. Review any changes in the context of your threat model — especially allow_unsafe_interrupts, which weakens IOMMU isolation. Security best practices in this area continue to evolve.
GPU Passthrough on Proxmox: Step-by-Step GuideProxmox VE is a free and open-source virtualization platform built on Debian. It supports KVM virtual machines, LXC containers, ZFS storage, clustering, backups, live migration, and high-availability features. For home labs, the big advantage is flexibility. You can run a Windows VM, a Linux server, Home Assistant, Docker, Pi-hole, Plex, Jellyfin, TrueNAS, or even pfSense on the same physical system. For small businesses or more advanced users, Proxmox can scale into multi-node clusters with shared storage and centralized management. The main tradeoff is that Proxmox is infrastructure software
Proxmox VE Guides: Setup, VMs, Containers, Backups, and Clustering… For home labs, the big advantage is flexibility. You can run a Windows VM, a Linux server, Home Assistant, Docker, Pi-hole, Plex, Jellyfin, TrueNAS, or even pfSense on the same physical system. …
… The official documentation is good, but real-world community discussions can be helpful for model-specific quirks, package issues, and home lab setups. r/Synology Unofficial Synology Forum Synology User Community on Facebook Final Thoughts A Synology NAS is one of the best options if you want relia… …
… Will GPU passthrough work if I’m also running Home Assistant on the same Proxmox host? …