For my own setups, I generally lean toward WireGuard when I want the VPN to be fully under my control and I’m already using a firewall or server that supports it. That is why I like WireGuard on pfSense, UniFi, OPNsense, or a Raspberry Pi. I would use Tailscale when I want remote access to work quickly, when port forwarding is not possible, when a device is behind CGNAT, or when I want easier multi-device management without manually building every peer relationship. Choose Tailscale if you want easy setup, no port forwarding, simple device management, CGNAT support, subnet routing, and exit no