As the title suggests, Prime Video's upcoming series takes place 50 years after Blade Runner 2049, and 80 years after the original Blade Runner. Replicants (bioengineered humanoids) have taken control of Earth, pushing humanity into a subservient role as oppressed, second-class citizens. Against the backdrop of this dystopian vision of Los Angeles, two detectives hunt down a group of criminal Replicants.
The series stars Michelle Yeoh as Olwen, a Replicant Blade Runner who knows her synthetic body will shut down soon from old age. Hunter Schafer co-stars as Olwen's partner Cora, a human who has to pretend to be a Replicant to get by. The rest of the cast includes Dimitri Abold, Lewis Gribben, Katelyn Rose Downey, Daniel Rigby, Johnny Harris, Amy Lennox, Sheila Atim, Matthew Needham, Tom Burke, and Maurizio Lombardi. One person who definitely won't be in the cast? Harrison Ford.